Human Sera
Cayman Chemical α-Piperidinobutiophenone (hydrochloride), Purity: ≥98%, CAS: 92728-82-0, 50 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical Leu-Enkephalin (trifluoroacetate salt), Purity: ≥98%, CAS: 73563-78-7, 50 mg
A neuropeptide and δ- and µ-opioid receptor agonist (Kis = 4.0 and 3.4 nM, respectively); selective for δ- and µ- over κ-opioid receptors (Ki = >1,000 nM); decreases the visceromotor response to colon distension in a mouse model of visceral pain induced by colorectal distension at 1 mg/kg; increases the tail-flick threshold and latency to tail flick in the tail-pressure test and tail-flick test, respectively
Cayman Chemical 10-Deacetylbaccatin III, Purity: ≥98%, CAS: 32981-86-5, 50 mg
An inhibitor of microtubule assembly (IC50s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively); a precursor in the semisynthetic synthesis of paclitaxel; inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM)
Cayman Chemical Vilazodone (hydrochloride), Purity: ≥95%, CAS: 163521-08-2, 100 mg
An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg
Cayman Chemical 5′-O-(4,4′-Dimethoxytrityl)thymidine, Purity: ≥98%, CAS: 40615-39-2, 50 mg
A derivative of thymidine and synthetic precursor; has been used as a precursor in the synthesis of oligo-2’-deoxyribonucleotides and phosphoramidate derivatives
Cayman Chemical Nicergoline, Purity: ≥98%, CAS: 27848-84-6, 100 mg
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 µg/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Cayman Chemical Biotinyl hexylamine, Purity: ≥98%, CAS: 65953-56-2, 50 mg
A synthetic intermediate; has been used in the synthesis of ANANAS and chemotherapeutic conjugates
Cayman Chemical β-Glucogallin, Purity: ≥98%, CAS: 13405-60-2, 50 mg
A plant metabolite and an aldose reductase 2 inhibitor (IC50 = 17 µM); inhibits glucose-induced sorbitol accumulation in lenses isolated from a transgenic mouse model overexpressing AKR1B1; reduces methylglyoxal-induced increases in COX-2, IL-6, IL-8, CCL2, and RAGE levels in ARPE-19 retinal epithelial cells
Cayman Chemical Acetyl Tetrapeptide-9 (acetate), Purity: ≥95%, 100 mg
A synthetic signal peptide; stimulates lumican synthesis in vitro
Cayman Chemical Cinnamoylglycine, Purity: ≥98%, CAS: 16534-24-0, 50 mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical Nα-Benzoyl-L-Arginine-pNA (hydrochloride), Purity: ≥98%, CAS: 21653-40-7, 50 mg
A colorimetric substrate for trypsin and papain; enzymatic cleavage releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of trypsin or papain activity
Cayman Chemical 3-Hydroxy-4-methyl-2(5H)-thiophenone, Purity: ≥98%, CAS: 34876-35-2, 50 mg
A degradation product of cefaclor; formed under aqueous acidic conditions
Cayman Chemical 3,3′-Dipropylthiadicarbocyanine (iodide), Purity: ≥98%, CAS: 53213-94-8, 50 mg
A fluorescent dye; has been used to monitor cell membrane potential; ex/em = 622/670 or 622/688 nm when cells are depolarized or hyperpolarized, respectively; fluorescence intensity decreases in hyperpolarized cells and increases in depolarized cells; induces membrane hyperpolarization, increases in intracellular sodium, and decreases in intracellular potassium in Ehrlich ascites tumor cells at 3 µM; increases potassium membrane permeability by 64.6% in Ehrlich ascites tumor cells in the presence of ouabain; reduces cellular ATP levels in the absence of glucose and induces acid production and inhibits oxygen consumption in the presence of glucose in Ehrlich ascites tumor cells at 3 µM
Cayman Chemical N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid methyl ester, Purity: ≥95%, CAS: 25875-99-4, 100 mg
A bacterial neuraminidase inhibitor (Ki = 48 µM for the A. sialophilus enzyme)
Cayman Chemical Trovafloxacin (mesylate), Purity: ≥98%, CAS: 147059-75-4, 50 mg
A broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 µg/ml) and DNA gyrase (IC50 = 7.13 µg/ml)