Human Sera
Cayman Chemical ACtyl TetrapeptID3ACTAt 100mg
A cephalosporin antibiotic active against clinical isolates of S aureus S epidermidis S pyogenes E coli K pneumoniae P mirabilis P vulgaris P morganii S marcescens and E cloacae in vitro (MICs 0 013-6 25 g/ml) active against various Gram-positive and Gram-negative bacterial infections in mice (ED50s 0 016-66 mg/kg) increases survival in a mouse model of K pneumoniae infection (SD50 7 6 mg/kg) curative in a mouse model of P mirabilis urinary tract infection (CD50s 0 4-0 75 mg/kg)
Cayman Chemical Crotonsde 50mg
A histamine H1 receptor antagonist (Ki 10 nM in COS-7 cells expressing the human receptor) completely inhibits response to histamine in guinea pigs when administered at a dose of 1 mg/kg
Cayman Chemical Setpprnt 50mg
An anticonvulsant shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1000 mg/kg decreases the duration of the tonic phase of seizures at a dose of 1000 mg/kg but does not affect the duration of the clonic phase at any dose decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60 respectively of control when administered at a dose of 20 mg/kg i p for 16 days
Cayman Chemical 1PalmItoyl2Oleoyl3ArachI 50mg
An internal standard for the quantification of letrozole by GC- or LC-MS
Cayman Chemical DIdocosnoIn 50mg
A neonicotinoid insecticide an agonist of insect nAChRs activates nAChRs containing N lugens a1 and rat B2 subunits (EC50 67 UM in X laevis oocytes) leads to sexual and aggressive behaviors in adult male offspring after administration to pregnant mice (1 mg/kg) decreases anxiety-like behavior of adult male offspring in the light-dark transition test (1 and 10 mg/kg)
Cayman Chemical R-CetIrIzInhydrochlorIde 50mg
A long-acting B2-AR agonist with bronchodilator actions inhibits TGF-a-induced hepatocyte DNA syntheses and proliferation in vitro (IC50 15 nM) dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria respectively isolated from guinea pig (pD2s 6.4 7.08 and 6.61 respectively)
Cayman Chemical Curcuma zdoara Curcumol 100mg
An antibiotic reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner when administered at doses ranging from 25-100 mg/kg prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection
Cayman Chemical ButyrylLcarnItInchlorIde 100mg
An antagonist of muscle-type nAChRs (IC50 14.8 nM) acts as a non-depolarizing neuromuscular blocking agent enhances isoflurane anesthesia (ED50 1.62 Ug/kg to reduce immobilization)
Cayman Chemical Tocopherol 50mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s 1 and 100 nM respectively) blocks IL-8-induced leukocyte recruitment (IC50 1 nM) and other inflammatory responses without affecting receptor activation induced by other CXCR1 and CXCR2 agonists at 100 nM depletes a cancer stem cell population in human breast cancer cell lines in vitro
Cayman Chemical LuteolosIde 50mg
A reactive probe that is used to biotinylate carboxyl or vicinal hydroxyl groups on carbohydrates glycoproteins or other glycoconjugates also used to link biotin to antibodies and ribonucleotides
Cayman Chemical -GalocatechIn 50mg
A glycine-conjugated form of lithocholic acid increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid decreased in the plasma by PEG-obestatin(Cys10 Cys13) in lean or diet-induced obese mice serum levels increase with age in children
Cayman Chemical LIgnocRIc ACD methyl STR 100mg
An inhibitor of lysosomal acid lipase (IC50 68 nM) selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 UM reduces cholesterol accumulation in lysosome-like storage organelles in NPC1-deficient GM03123 cells (0.01-10 UM)
Cayman Chemical trns-nrolIdol 50mg
An antiparasitic and antimicrobial 5-nitroimidazole derivative metabolized to cytotoxic intermediates that induce irreversible DNA damage efficacious against clinically significant bacteria and protozoa
Cayman Chemical nglca ctodoa nc Mamsn 50mg
A FAK inhibitor selective for FAK over 261 kinases inhibits FAK autophosphorylation at Y397 in OVCAR8 ovarian U87MG glioblastoma and A549 lung cancer cell lines (IC50s 15 8.5 and 12 nM respectively) induces apoptosis decreases viability (IC50 25 UM) and inhibits colony formation in L3.6P1 cells leads to lower tumor weight and fewer metastases in an orthotopic mouse model of uterine cancer at 75 mg/kg per day
Cayman Chemical 10 ZNonadeceNIc ACD mthy 50mg
A synthetic corticosteroid reduces inflammation in rat models of carrageenan-induced plantar edema and air pouch granulomas (ID50s 1.85 and 4.2 mg/kg respectively) when administered topically